Abstract
High amounts of nitric oxide and TNF-α generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-α and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-α and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium.
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