Abstract
CRC is the second leading cancer globally, with a high lethality rate. The primary treatment of CRC is still surgery andchemotherapy with limited therapeutic effects. Quercetin, a component of traditional Chinese medicine, has shown itsability to anti-tumor and induce cell apoptosis through PI3K/AKT signalling pathway. This study aims to figure out howconcentrations of quercetin and different treatment durations will influence the effects of induction of apoptosis. Theexperiments will use CL40 cells. Cell apoptosis is measured by flow cytometry, and cell growth by MTT assay. Thephospho-AKT level is measured by anti-p-AKT Western Blot. Our research will determine the relationship betweentherapeutic effects, drug concentrations, and treatment durations. Further studies on the side effects of quercetin andmethods to mitigate the side effects in the systematic use of quercetin should be done. Moreover, a more specificmechanism for the function of quercetin is waiting to clarify
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