Abstract
Objectives: Unmodified solid organs from pigs perfused with human blood undergo hyperacte rejection within minutes to hours. This reaction is mainly triggered by preformed anti-pig-antibodies binding to endothelial cell structures. Subsequent activation of the complement system causes endothelial cell damage, edema and venulothrombosis. Quercetin glucuronide (QG) was reported to stabilize cultured endothelial cells of venular origin in presence of inflammatory mediators and blood cells. We now investigated an assumed protective action of this substance in isolated hearts.
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