Abstract
In the article was studied the effects of flavonol quercetin on indices of adaptive immune response in experimental animals on the 14th day of the experimental bacterial-immune periodontitis development. Indices of immune protection were determined by the relative number of lymphocytes with CD3+, CD4+, CD8+, CD19+, CD16+ and immunoregulatory index (CD4+ / CD8+) in intact animals and on the 14th day of inflammatory process development in periodontal tissues as well as the therapeutic effects of flavonol quercetin. As a result of the study, characterized changes associated with the activity of both the cell-mediated and humoral-immune response were found, both in the development of experimental periodontitis, and apply of flavonol. In particular, there was an increase in the animal’s blood relative amount of CD8+, CD16+ cells on the 14th day, and content of CD3+, CD4+, CD19+ was decreased. In this case, the immunoregulatory index (CD4+ / CD8+) as an important index of immunological activity was decreased. The apply of flavonol quercetin in the period development of bacterial-immune periodontitis animals functional activity of the T-cell line of the immune system was increased, as evidenced percentage increase of B- and T-cells due to T-helper cells decrease as well as T-killers content during this period of inflammatory reaction in the periodontal complex, in comparison with animals, which were not treated.
Highlights
Inflammatory diseases of periodontal tissues are widespread in the world
Experimental animals were divided into three groups: the first group – intact animals (n = 10); the second group – animals with experimental periodontitis on the 14th day of the study (n = 8), and third group – animals with experimental periodontitis on the 14th day of the study, which was treated by quercetin (n = 8)
The therapeutic use of this flavonol caused increase of common mature T-lymphocytes (CD3+) by 1.43 times (p
Summary
Inflammatory diseases of periodontal tissues are widespread in the world. The etiology and pathogenesis of periodontal diseases are complicated, insufficiently elucidated and one of the important problems of theoretical and practical medicine (Demkovych et al 2019). Demkovych A et al.: Quercetin effects on adaptive immune response in periodontitis reaction of the whole organism to the bacterial invasion of periodontal tissues. It is known that the development of periodontitis is a result of an imbalance between the microflora of the oral cavity, its barrier characteristics and immune protection of the organism (Thumbigere-Math et al 2014). It should take into account the adequate activity of the inflammatory cells and adequacy of the resistance mechanisms (Cekici et al 2014). Inflammatory diseases of periodontal complex, as a rule, chronicity, with periodic remissions, that considers necessity of timely and repeated treatment course (Silva et al 2014)
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