Abstract
Postprandial hyperglycemia is a major risk factor for diabetic co mp licat ions leading to disabilities and mortality in diabetics. Quercetin, a flavonoid, has been tried in trad itional med icine for treat ing many disorders including diabetes. The present study was designed to evaluate the potential of quercetin to damp postprandial blood glucose level after maltose and glucose loading in patients with type 2 diabetes mellitus (DM). In a rando mized, b linded crossover study, single oral dose (400mg ) of quercetin or placebo formula was ad min istered to the patients 30 min before loading with either maltose (2g/kg) or g lucose (100g), blood samp les are taken at different intervals for measurement of plas ma g lucose. The results clearly showed amelio rated postprandial hyperglycemia due to the use of quercetin, it significantly dampened the postprandial hyperglycemia only after maltose loading compared to placebo; no effect reported for quercetin after glucose loading. In conclusion, quercetin effectively suppresses postprandial hyperglycemia in patients with type 2 DM loaded with maltose, which may be attributed to α-glucosidase inhibition.
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