Abstract
BackgroundQuercetin was reported to be crucial for a broad range of activities, including attenuating inflammation, platelet aggregation, capillary permeability, and lipid peroxidation. However, the effect of quercetin in hypertension during pregnancy, was not fully understood.MethodsThe model of hypertension in pregnancy was established in rats by reduced uterine perfusion pressure (RUPP). Quercetin was administrated by gavage. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using the CODA 6 BP system. Plasma concentrations of Endothelin-1 (ET-1), soluble fms-like tyrosine kinase-1 (sFlt-1), and vascular endothelial growth factor (VEGF) were detected using enzyme-linked immunosorbent assay kits. The mRNA and protein levels of ET-1 and endothelin-1 type A receptor (ETAR) were determined by RT-PCR and Western blotting. The ETAR antagonist BQ-123 was performed by osmotic minipumps.ResultsIn RUPP induced rats, quercetin treatment decreased SBP and DBP, fetal resorptions percentage, plasma ET-1 and sFlt-1 concentrations, ET-1 and ETAR levels, but increased fetal body weight and VEGF expression. BQ-123 administration attenuated SBP and DBP, suppressed fatal resorptions percentage, and increased fetal body weight of RUPP rats.ConclusionQuercetin attenuates RUPP induced hypertension in pregnant rats through the regulation of ET-1 and ETAR.
Highlights
Hypertension in pregnancy is the disease that developed in mother gestation of 20 weeks or longer and is one of the leading causes of morbidity and mortality for mother and baby around the world [1, 2]
Quercetin treatment significantly suppressed diastolic blood pressure (DBP) of reduced uterine perfusion pressure (RUPP) rats from day 15 to day 19 (Fig. 1b). These results demonstrated that quercetin treatment decreased blood pressure during the middle to the late gestation period of RUPP rats
Quercetin treatment protects fetal body of RUPP rats The effect of quercetin on protecting the fetal body of RUPP rats was further explored
Summary
Hypertension in pregnancy is the disease that developed in mother gestation of 20 weeks or longer and is one of the leading causes of morbidity and mortality for mother and baby around the world [1, 2]. Various studies reported the effect of quercetin in anti-hypertension both in human and animal models. Intake of 150–730 mg quercetin for 4 to 10 weeks showed the anti-hypertensive effect in human. For stage 1 hypertensive patients, a high dose (730 mg daily) of quercetin intake significantly suppressed systolic blood pressures (SBP) and diastolic blood pressures (DBP), while high dose quercetin showed no effect for prehypertension patients [10]. In a hypertensive rat model, 10− 5 M quercetin treatment increased acetylcholineinduced vascular relaxation [12], demonstrating that quercetin suppressed blood pressure by attenuating the blood vessel elastance. The effect of quercetin on hypertension in pregnancy remains unclear and the mechanism is still waiting for exploration. The effect of quercetin in hypertension during pregnancy, was not fully understood
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
