Abstract
This study aimed to investigate the effects of quercetin (QUE) on fat deposition and the underlying mechanism. Fish were fed four test diets: normal fat diet (NFD), high-fat diet (HFD), and HFD supplemented with 0.5 or 1.0 g/kg quercetin (QUE0.5 or QUE1.0). The results showed that HFD feeding resulted in poor growth and feed utilization while QUE treatment reversed this. The fat contents of serum and liver were increased by HFD and QUE supplementation significantly decreased fat content. Furthermore, gene expressions and ultrastructure observation showed that mitochondrial biogenesis and mitophagy were inhibited and endoplasmic reticulum stress (ERS) in the HFD group. QUE can activate the biogenesis and autophagy of mitochondria and suppress ERS, which is related to its fat-lowering effect.
Highlights
Fat plays a key role in metabolism as it supplies energy, essential fatty acids, and phospholipids for animals (Watanabe, 1982)
weight gain (WG) and specific growth rate (SGR) were significantly increased in the two QUE groups (P < 0.05), and fish in the QUE1.0 group exhibited the highest WG
Fish-fed high-fat diet (HFD) showed excess fat deposition in the liver comparing to other groups
Summary
Fat plays a key role in metabolism as it supplies energy, essential fatty acids, and phospholipids for animals (Watanabe, 1982). Recent studies have indicated that the intake of high fat diet (HFD) often induces excess fat deposition, metabolic disorders, and immune dysfunction (Jin et al, 2013; Lu et al, 2014; Xie et al, 2021a; Yin et al, 2021). It is well-known that fat deposition in the liver represents complex processes, such as uptake, oxidation, transport, and so on (Tilg and Moschen, 2010; Rocha et al, 2020).
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