Quercetin and Related Chromenone Derivatives as Monoamine Oxidase Inhibitors: Targeting Neurological and Mental Disorders

Priyanka Dhiman,Eugenio Uriarte,Eduardo Sobarzo-Sánchez,Neelam Malik,Anurag Khatkar

doi:10.3390/molecules24030418

Abstract

Monoamine oxidase inhibitions are considered as important targets for the treatment of depression, anxiety, and neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. This has encouraged many medicinal chemistry research groups for the development of most promising selective monoamine oxidase (MAO) inhibitors. A large number of plant isolates also reported for significant MAO inhibition potential in recent years. Differently substituted flavonoids have been prepared and investigated as MAO-A and MAO-B inhibitors. Flavonoid scaffold showed notable antidepressant and neuroprotective properties as revealed by various and established preclinical trials. The current review made an attempt to summarizing and critically evaluating the new findings on the quercetin and related flavonoid derivatives functions as potent MAO isoform inhibitors.

Highlights

Depression and anxiety are estimated as incapacitating mental disorders which impose a huge health burden globally
Docking methodologies revealed that the quercetin can thoroughly bind within the active site of the oxyethyldaidzein
The monoamine oxidase (MAO) inhibiting capacity of quercetin. This special character of OH and ring B found unique as compared to xanthones, doofnot require and catechol forFlavonoid the betterDerivatives restricting association with MAO

Summary

Introduction

Depression and anxiety are estimated as incapacitating mental disorders which impose a huge health burden globally. Alzheimer’s disease is indicated by nerve cells die in the cerebral cortex and accounts for 60 to 80 percent of dementia cases which affected more than 25 million people worldwide in 2000 and may eventually to increase to 114 million by 2050 [6,7,8,9]. General treatment of this disease is the utilization of dopaminergic agonists. The current review made an attempt to identify the MAO inhibition property of quercetin and related derivatives and establish the rational design of new MAOIs from this investigation

Chemistry and Therapeutic Journey of Quercetin and Related Derivatives

Flavanoids

Molecular Docking Studies of Quercetin and Related Flavonoid Derivatives

Molecular

Findings

Design of the out