Quercetin action on health and female reproduction in mammals

Abstract

This paper reviews the current information concerning availability, metabolism of quercetin, its effects on physiological processes and illnesses with focus on the effects, mechanisms of action and areas of possible application of quercetin in control of female reproductive processes, prevention and treatment of their disorders in mammals. The available information demonstrated the ability of quercetin and its analogues to inhibit proliferation and to promote apoptosis, to activate regenerative processes, to treat immune, inflammatory, cardiovascular, neurodegenerative, gastric and metabolic disorders and cancer, to suppress microorganisms, to protect bones and liver, to relieve pain, to improve physical and mental performance, and to prolong life span. The positive influences of quercetin on mammalian female reproductive processes are well documented. It can promote ovarian follicullo- and oogenesis, improve quality of oocytes and embryos, increase fecundity in various species. These effects can be mediated by changes in pituitary and ovarian hormones, growth factors and cytokines, in their receptors and post-receptory signaling pathways. Due to these effect, quercetin can be applicable as biostimulator of reproduction, for prevention, mitigation and treatment of several female reproductive disorders, as well as to increase resistance of female reproductive system to adverse effect of chemotherapy, temperature stress and environmental contaminants.