Abstract
Quercetagetin and patuletin were extracted by the same method from two different Tagetes species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer agent. Their biological activity (IC50 and necrotic, apoptotic and selective activities of these flavonols) was evaluated and compared to that of quercetin, examining specifically the effects of C6 substitution among quercetin, quercetagetin and patuletin. We find that the presence of a methoxyl group in C6 enhances their potency.
Highlights
IntroductionThe urgent need to obtain new drugs to treat it arises from the fact that conventional treatments cause many side effects that negatively impact patients’ quality of life
Cancer is one of the most severe public health problems worldwide
(3)structure were isolated by the same method2 from quercetin, we found that they share a basic flavonol structure type and that the only difference is the different species of Tagetes plants
Summary
The urgent need to obtain new drugs to treat it arises from the fact that conventional treatments cause many side effects that negatively impact patients’ quality of life. This has fostered the use of plant extracts and their metabolites as sources of active compounds [1]. It is highly-esteemed as an ornamental plant, and in some parts of the world is has ritual-cultural importance [3]. Several species of Tagetes are found in Mexico, some known commonly as Cempasuchil or Cempoalxochitl [4]. Two representative species are Tagetes erecta and Tagetes patula [5], both of which have important therapeutic potential due to their antiparasitic, antimalarial, anti-inflammatory, antitumorogenic and antiviral effects [6]
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