Abstract
The present study focused on the vibration of micro crystal particles of guanine due to Brownian motion. The organic particle has a refractive index of 1.83 and caused a flickering of light. To test the possibility of using magnetic properties under wet conditions, changes in the frequency of particle vibration by applying magnetic fields were investigated. At first, we found that the exposure at 5 T inhibited the flickering light intensities and the particle vibration slightly decreased. Next, we carried out a high speed camera measurement of the Brownian motion of the particle with a time resolution of 100 flame per second (fps) with and without magnetic field exposures. It was revealed that the vibrational speed of synthetic particles was enhanced at 500 mT. Detailed analyses of the particle vibration by changing the direction of magnetic fields versus the light source revealed that the Brownian motion’s vibrational frequency was entrained under magnetic fields at 500 mT, and an increase in vibration speed to 20Hz was observed. Additional measurements of light scattering fluctuation using photo-detector and analyses on auto-correlation also confirmed this speculation. The studied Brownian vibration may be influenced by the change in mechanical interactions between the vibration particles and surrounding medium. The discovered phenomena can be applied for molecular and biological interactions in future studies.
Highlights
The demand for new functional biological markers for the biomedical industry has recently increased tremendously
The flickering and Brownian motion of the synthetic guanine crystals was observed with a CCD microscope and captured using a high speed camera
The results show that the mean intensity of the individual synthetic guanine particles distinctly decreased at 5 T, while the standard deviation of the intensity, i.e., the fluctuation in motion caused by Brownian motion, decreased but was not so distinct
Summary
The demand for new functional biological markers for the biomedical industry has recently increased tremendously. Excitation of biological molecules releases fluorescence, which is used for diagnosis of neoplastic and non-neoplastic lesions.[6] Caries detection is enhanced by QLF which detects the alteration of light scattered by molecules due to variation in mineral content of enamel. A similar principle is used by FOTI and the Digitized-FOTI for caries detection.[7] Use of such advanced technology has helped in early and minimally invasive diagnosis, clear quantification of disease with an overall decline in undetected cases. Under the wet conditions in which biological reactions take place, biogenic materials with high reflectivity offer an efficient way to enhance the signal to noise ratio for light detection in an aqueous medium. It was found that biogenic guanine crystals showed a quick response to external magnetic fields where the crystal platelets oriented parallel to the magnetic field and distinctly switched the intensity of light reflection.[10,11,12,13] The present study focused on assessing the dynamic behaviour of guanine by using synthetic guanine crystals
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