Que faut-il connaître de la classification anatomopathologique des cancers pulmonaires ?: What do we need to know about the new histomolecular classification of lung cancers?

Abstract

The latest WHO classification of thoracic tumors published in 2021 has integrated morphology, immunohistochemistry and molecular techniques, with greater emphasis on genetic testing than the 2015 WHO classification. Its major features include a section devoted entirely to the classification of small samples, their management and the immunohistochemical and molecular analyses to be performed. It provides guidelines concerning the histological subtyping of invasive non-mucinous adenocarcinomas and their grading, as well as their staging according to the new 8th edition pTNM classification, recognises the Spread Through Air Spaces (or STAS) as a poor prognostic factor. This new classification proposes a new terminology for pulmonary neuroendocrine neoplasms more in line with that of extrathoracic neuroendocrine tumors, and describes new entities such as bronchiolar adenoma, papillary muconodular ciliated tumor and SMARCA4-deficient tumors. Lastly for each tumor at the end of each chapter, essential and desirable criteria for its diagnosis are provided, as well as access to demonstrative virtual slides.1877-1203/© 2023 SPLF. Published by Elsevier Masson SAS. All rights reserved.