Abstract
Fro m this study, methods for quantitative analysis were developed to determine cefuro xime sodiu m in the raw material and in pharmaceutical formulat ions. These tests included instrumental methods such as spectrophotometry in the ultraviolet, visib le and infrared, h igh performance liquid chromatography and potentiometric determination by microbio logical methods (agar diffusion and turbidimetric). The concentration range determined fo r each method varied greatly, which increases the usability of cefuro xime fori dentify ing quality control. In spectrophotometric methods cefuro xime was determined fro m 5.0μg/ ml to 2.0mg/ mL.The microb iological methods have determined the drug concentration 30.0-120.0 μg/ml and HPLC ranged fro m 10.0to15.0μg/ ml.The results obtained by analysis of the dosage form were co mpared to results obtained by analysis of the reference substance and showed significance. These methods proved to be reproducible and rapid determination of cefuro xime can be routinely used in quality control analysis.
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