Abstract
Three 2,4,6-(dialkylaminoalkoxy)-1,3,5-triazines, two 2,4-(dialkylaminoalkoxy)-quinazolines, seven tris quaternar salts of the triazines and three bis quaternary salts of the quinazolines were prepared and identified. Seven of the quaternary salts were tested for curariform activity by the mouse screen-drop test and the rabbit head-drop test. In the chick, the quaternary salts produced a flaccid paralysis associated with a pachycurare-type block. Of the seven compounds tested, six were appreciably less active than Flaxedil®. One compound, the tribenzchloride of 2,4,6-(β-diethyl-aminoethoxy)-1,3,5-triazine, was approximately twice as active as Flaxedil® in the mouse and seven times as active in the rabbit.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Pharmaceutical Sciences (Scientific Edition)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
