Abstract
Three 2,4,6-(dialkylaminoalkoxy)-1,3,5-triazines, two 2,4-(dialkylaminoalkoxy)-quinazolines, seven tris quaternar salts of the triazines and three bis quaternary salts of the quinazolines were prepared and identified. Seven of the quaternary salts were tested for curariform activity by the mouse screen-drop test and the rabbit head-drop test. In the chick, the quaternary salts produced a flaccid paralysis associated with a pachycurare-type block. Of the seven compounds tested, six were appreciably less active than Flaxedil®. One compound, the tribenzchloride of 2,4,6-(β-diethyl-aminoethoxy)-1,3,5-triazine, was approximately twice as active as Flaxedil® in the mouse and seven times as active in the rabbit.
Published Version
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