Abstract
This study used quaternary ammonium functionalized magnetic beads (QAMBs) as magnetic solid-phase extraction (MSPE) sorbents and liquid chromatography-tandem mass spectrometry (LC-MS) to analyze five folates in a way that was both effective and sensitive. The developed magnetic beads had high BET surface areas up to 434.4 m2/g and strong positive zeta potentials above 40 mV. The conditions for MSPE were optimized. Under the chosen conditions, the linear ranges of the studied folates were 10–10000 ng/L, and the LODs were found to be 1 ng/L. This method was also successfully applied to analyze human plasma samples, giving satisfactory results (recovery of 86.4–98.8 %) and accomplishing it in a short time (i.e., 5 min). The proposed method would be employed for detecting other acids in blood.
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