Abstract
Available contact assays for blood plasma and whole blood coagulation have low predictive power in patients with coagulopathy or take a significant amount of time and blood volume to obtain diagnostic data. We have developed an innovative low-volume non-contact technology for real-time assessment of blood coagulation, referred to as “Quasi-static Acoustic Tweezing Thromboelastometry”(QATT). In our method, human blood drops with volume less than 5 microliter (~100 times smaller than the volume required by current coagulation technologies) are levitated in air by acoustic radiation forces. The sample drop location and deformation are induced by a quasi-static change in the acoustic pressure. By extracting a linear regime slope, the samples exhibit a unique elasticity profile over time (tweezograph) less than 20 minutes, characterized by clot initiation time (CIT), time to firm clot formation (TFCF), and maximum clot strength (MCS). The exposure of blood samples to pro- or anti-thrombotic agents (Fibrinogen ...
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