Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity.

Michał Gacki,Anna Pietrzak,Wojciech M Wolf,Izabela Korona-Głowniak,Karolina Kafarska

doi:10.3390/molecules25133099

Abstract

Three metal complexes of mefenamato ligand 1 were synthesized: [Co2(mef)4(EtOH)2(H2O)4]: 2; [Co(mef)2(MeOH)4]∙2MeOH: 3; and [Ni(mef)2(MeOH)4]∙2MeOH: 4. Their compositions and properties were investigated by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Crystal structures were determined by the single crystal X-ray diffraction technique. Additionally, their antioxidant and antimicrobial activity were established, thus proving good/moderate bioactivity against Gram-positive bacteria and yeasts. In the crystal structure of 2, an apical water molecule is shared between two adjacent cobalt(II) ions, resulting in the formation of a polymeric chain extending along the [100] direction. Meanwhile, structures 3 and 4 have strong intermolecular hydrogen bonds with diverse topologies that yield unique quasi-isostructural arrangements. The packing topology is reflected by the Hirshfeld surface analysis of intermolecular contacts.

Highlights

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most popular pharmaceuticals that have been used against inflammation, pain, and fever over the years [1]
We report the successful crystallization and crystal structures of three mefenamato complexes: 2–4 (Scheme 1)
The crystal structures of 2–4 were determined by the single crystal X-ray diffraction antioxidant studies; see Table 1

Summary

Introduction

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most popular pharmaceuticals that have been used against inflammation, pain, and fever over the years [1]. Their therapeutic effect is mainly based on their ability to inhibit the conversion of the arachidonic acid to prostaglandins [2]. The structural similarity of crystals [9] plays a vital role in understanding the pharmaceutical activity of solid-state drugs. It is often described by the term isostructurality [10] and is profoundly associated with intermolecular interactions and often prompted by symmetry restrictions. That quasi-isostructurality was observed in systems 3 and 4

Methods

Results

Conclusion