Abstract
Planar lipid bilayer (PLB) apparatus provide an excellent platform for the study of isolated membrane proteins. The noise performance and bandwidth of PLB systems are poor relative to the state of the art in patch clamp/pipette apparatus. The problem is the relatively high capacitance of PLB systems relative to small area patch pipettes. At low frequencies (hundreds of Hz), the difference is small to non-existent. At higher frequencies, the noise becomes dominated by voltage noise from the amplifier acting on capacitance of the lipid bilayer and surrounding platform.
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