Abstract
Hydroxylapatite (HA) nanoparticles were conjugated with quantum dots (QDs) for in vivoimaging. The surface structures of HA nanoparticles with conjugated quantum dots(HA-QD) were studied by transmission electron microscopy (TEM) and laserfluorescent spectroscopy. The TEM data showed that the quantum dots were wellconjugated on the HA nanoparticle surfaces. The laser fluorescent spectroscopyresults indicated that the HA-QD exhibited promising luminescent emission invitro. The initial in vivo experiments revealed clear images of HA-QD from thehypodermic injected area at the emission of 600 nm. Furthermore, the optimized in vivoimages of HA-QD with near-infrared emission at 800 nm were visualized afterintravenous injection. These luminescent HA-QD nanoparticles may find importantapplications as biodegradable substrates for biomarkers and in drug delivery.
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