Quantitative volumetric analysis of progressive hemifacial atrophy corrected using stromal vascular fraction-supplemented autologous fat grafts.

Abstract

Progressive hemifacial atrophy (Parry-Romberg disease) is rare and involves all skin layers and subcutaneous soft and hard tissue. Autologous fat grafting has revolutionized the field of soft-tissue reconstruction and augmentation, but long-term maintenance is unpredictable. Stromal vascular fraction (SVF)-supplemented cell therapy offers new hope for improving fat graft survival, with good long-term results, but efficacy and long-term outcome in the clinic are rarely studied using objective data. To compare the long-term viability of SVF-supplemented fat grafts and fat grafts alone for contour reconstruction of progressive hemifacial atrophy using quantitative volume analysis. We treated 20 patients with stable hemifacial atrophy for at least 2years with SVF-supplemented autologous fat grafting (n=10) or fat grafting alone (n=10). All patients were followed up every 3months. Hemifacial volume was measured using computed tomography and the Philips Extended Brilliance Workspace. All patients had successful outcomes without complications, but fat survival and clinical improvement was greater with SVF-supplemented grafting than fat grafting alone after 6months. SVF-supplemented autologous fat transplantation is effective and safe for treating progressive hemifacial atrophy and can enhance the survival of grafts in the face without major complications.