Abstract
Conventional ultrasound, which is routinely used for diagnostic imaging applications, is mainly qualitative. However, novel quantitative ultrasound (QUS) imaging modes are being adapted to quantify tissue properties for diagnosing disease, classifying tissues and monitoring and assessing therapy. Ultrasound is a propagating wave that interacts with a medium as a function of the spatially-dependent mechanical properties of the medium. By analyzing the backscattered wave, various properties of the propagating media can be quantified. QUS techniques based on parameterizing spectral features and envelope statistics of the backscattered signal were used to monitor and assess therapy from high intensity focused ultrasound (HIFU) treatment. QUS parameters were obtained by fitting theoretical models to backscatter coefficients (BSCs) that are estimated from backscattered radiofrequency signals. Additional parameters were estimated by fitting the homodyned K distribution to the statistics of the envelope of the backscattered signal. These parameters can be related to tissue properties and microstructure, such as the shape, size and organization of microstructure. Experimental results will be presented to demonstrate the applicability of QUS imaging to monitor and assess HIFU treatments on mouse mammary tumors.
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