Abstract
PurposeNeuromelanin is a dark pigment granule present within certain catecholamine neurons of the human brain. Here, we aimed to clarify the relationship between contrast of neuromelanin-sensitive magnetic resonance imaging (MRI) and MR relaxation times using T1, T2, and T2* mapping of the lower midbrain.MethodsThe subjects were 14 healthy volunteers (11 men and 3 women, mean age 29.9 ± 6.9 years). Neuromelanin-sensitive MRI was acquired using an optimized T1-weighted two-dimensional (2D)-turbo spin-echo sequence. To quantitatively evaluate the relaxation time, 2D-image data for the T1, T2, and T2* maps were also acquired. The regions of interest (substantia nigra pars compacta [SNc], superior cerebellar peduncles [SCP], cerebral peduncles [CP], and midbrain tegmentum [MT]) were manually drawn on neuromelanin-sensitive MRI to measure the contrast ratio (CR) and on relaxation maps to measure the relaxation times.ResultsThe CR in the SNc was significantly higher than the CRs in the SCP and CP. Compared to the SCP and CP, the SNc had significantly higher T1 relaxation times. Moreover, the SNc had significantly lower T2 and T2* relaxation times than the other three regions (SCP, CP, and MT). Correlation analyses showed no significant correlations between the CRs in the SNc, SCP, and CP and each relaxation time.ConclusionsWe demonstrated the relationship between the CR of neuromelanin-sensitive MRI and the relaxation times of quantitative maps of the human midbrain.
Highlights
Neuromelanin, the dark pigmented granules present in the human central nervous system, was discovered in the 1930s [1]
The contrast ratio (CR) in the substantia nigra pars compacta (SNc) was significantly higher than the CRs in the SCP and CP
Correlation analyses showed no significant correlations between the CRs in the SNc, SCP, and CP and each relaxation time
Summary
Neuromelanin, the dark pigmented granules present in the human central nervous system, was discovered in the 1930s [1]. Neuromelanin is present within certain catecholamine neurons of the human brain, such as the dopamine and noradrenaline-containing neurons of the substantia nigra pars compacta (SNc) [1, 2]. PD is a neurodegenerative disorder caused by the selective death of pigmented SNc neurons [3, 4], which leads to dopamine depletion in the neostriatum [5] and results in a clinical syndrome involving tremor, rigidity, and impaired motility. In 1988, it was reported that the neuromelanin-containing cells of the SNc are more vulnerable in PD [6]. Neuromelanin of the human midbrain could be a marker of neurodegenerative diseases
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