Abstract

Quantitative systems pharmacology (QSP) has emerged as an innovative approach in model‐informed drug discovery and development, supporting program decisions from exploratory research through late‐stage clinical trials. In this commentary, we discuss the unique value of disease‐scale “platform” QSP models that are amenable to reuse and repurposing to support diverse clinical decisions in ways distinct from other pharmacometrics strategies.

Highlights

  • For readers interested in learning more about Quantitative systems pharmacology (QSP), in addition to references cited below, tutorials, reviews, and original research papers are available through the journal CPT: Pharmacometrics & Systems Pharmacology

  • Successful application has set the stage for novel modeling approaches, including quantitative systems pharmacology (QSP).[2]

  • The above examples, and others discussed in the literature,[1,5] demonstrate the potential for QSP disease platforms to provide continued value across a range of projects and disease indications

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Summary

Introduction

For readers interested in learning more about QSP, in addition to references cited below, tutorials, reviews, and original research papers (along with technical detail allowing model reproduction) are available through the journal CPT: Pharmacometrics & Systems Pharmacology. Quantitative systems pharmacology (QSP) has emerged as an innovative approach in model-informed drug discovery and development, supporting program decisions from exploratory research through late-stage clinical trials.

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