Abstract
This study explored whether autoregulatory shifts in cerebral blood volume induce susceptibility changes large enough to be depicted by quantitative susceptibility mapping. Eight healthy subjects underwent fast quantitative susceptibility mapping at 3T while lying down to slowly decrease mean arterial pressure. A linear relationship between mean arterial pressure and susceptibility was observed in cortical and subcortical structures, likely representing vessels involved in autoregulation. The slope of this relationship is assumed to indicate the extent of cerebral vascular compliance.
Highlights
MethodsMR Imaging Eight healthy volunteers (6 men, 2 women) with a mean age of 32 years (age range, 28 – 49 years) participated in this explorative study, which was approved by the local ethics committee of the Medical University of Graz, Austria (EK 29-623 ex 16/17)
Quantitative susceptibility mapping (QSM) is a powerful technique to assess the magnetic susceptibility of tissue.[1]
This property is dominated by the diamagnetic susceptibility of water, but paramagnetic iron and diamagnetic lipids, proteins, or calcifications may cause regional susceptibility variations.[2]
Summary
MR Imaging Eight healthy volunteers (6 men, 2 women) with a mean age of 32 years (age range, 28 – 49 years) participated in this explorative study, which was approved by the local ethics committee of the Medical University of Graz, Austria (EK 29-623 ex 16/17). For QSM, we used a 3D gradient-echo echo-planar imaging (greEPI) sequence[11] with TR ϭ 50 ms, TE ϭ 30 ms, flip angle ϭ 15°, FOV ϭ 250 mm, in-plane resolution ϭ 0.65 ϫ 0.65 mm, slice thickness ϭ 1.5 mm, EPI factor ϭ 15, scan time ϭ 57 seconds. This sequence was started immediately after the volunteers had taken their supine position in the MR imaging scanner. Thereafter, a T1-weighted true inversion recovery sequence was performed with TR ϭ 6000 ms, TE ϭ 11 ms, TI ϭ 500
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