Abstract
This paper describes the quantitative structure-stability relationship of Tc vON 2S 2 compounds using a stability indicator based on the solid angle factor sum (SAS)_for predicting the in vitro stability. The SAS values of six Tc vON 2S 2 and one Tc vON 4 ( d,l-HMPAO) complexes were calculated from their x-ray crystallography data. The rank order of in vitro stability of these compounds, as measured by ligand exchange reaction, is directly related to that of the SAS values. The SAS values are potentially useful for predicting stability and designing new 99mTc radiopharmaceuticals.
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