Abstract
It has been found by Severinghaus (1934) and Wolfe (1934) that injections of extracts of pregnancy urine induce marked changes in the anterior pituitaries of immature female rats. The latter reported that such injections induced a marked increase in the weight of the ovaries of immature female rats and a variable increase in the weight of the pituitaries. The ovaries contained many corpora lutea, partially luteinized follicles and unluteinized follicles of all sizes. In the anterior pituitaries the most prominent morphologic changes were in the basophiles, which were usually enlarged and exhibited a marked loss of granules. Less outstanding was the morphologic evidence of loss of granules from the eosinophiles; this loss in most instances involved only a minority of the cells. The relative level of the eosinophiles was usually decreased, while that of the ehromophobes was increased. Of equal interest was the fact that these extracts were without effect on the anterior pituitaries of castrated female rats.
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