Abstract
In this research quantitative studies of Co(II)-thymoquinone complex was performed using cyclic voltammetry. The electrodes used were glassy carbon as working, saturated calomel as reference and platinum as auxiliary electrode. All the work was done at standard temperature (25 ± 1 °C) in aqueous medium using NaCl as supporting electrolyte. Effects of different parameters, i.e. concentration and metal-ligand ratios on complex formation were investigated. Observations obtained by varying the metal-ligand ratio suggested a quasi-reversible electron transfer process in the complex. The effect of concentration followed the Randles-Sevcik equation. Values of the standard electrode potential (E°), diffusion coefficient (D), transfer coefficients (α and β) and different electrochemical parameters were also calculated. The E° for the complex was found to be 0.288 ± 0.01V. The α values ranged between 0.676 ± 0.02 - 1.00 ± 0.02 whereas the values of β were found to be 0.758 ± 0.01 - 1.20 ± 0.01 respectively. Linear regression showed that cyclic voltammetry could be useful for the quantification of Co(II)-thymoquinone complex in pharmaceutical analysis.
Highlights
Cobalt is one of the trace elements which are essential for human health and is found as the key mineral of vitamin B12.1,2 It is necessary for the formation of erythrocytes, synthesis of DNA, RNA and myelin, red blood cells formation and in repairing nerve tissues
Quantitative studies of Co(II)-thymoquinone complex were carried out using cyclic voltammetry
The study indicates that linear regression can be applied for quantification of the studied complex within a wide linear range i.e. 0.02 × 10–3M to 1.2 × 10–3 M successfully
Summary
Cobalt is one of the trace elements which are essential for human health and is found as the key mineral of vitamin B12.1,2 It is necessary for the formation of erythrocytes, synthesis of DNA, RNA and myelin, red blood cells formation and in repairing nerve tissues. Calcium and vitamin B6 require it to perform their roles. Metabolism of some important nutrients such as carbohydrates and proteins takes place in the presence of vitamin B12.1 deficiency as well as toxicity of cobalt can cause several severe complications. Thymoquinone, shown, is a bio-active component of volatile oil of Nigella sativa[10,11] which has been found to possess hundreds of biological activities.[12,13,14,15,16,17] It is a strong antioxidant[17,18] and can form complexes with several metals.[19,20] These properties may play very important role in its pharmacological action
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