Abstract
Summary In continuation of earlier work a selected series of 20 pharmacologically interesting 1-amino-3-aryl-guanidines was synthesized by hydrazinolysis of corresponding 1-aryl-2-methyl-isothioureas. The compounds were isolated as hydronitrates and tested for algicidic activity using a standardized growth test based on autotrophically cultivated C hlorella vulgaris suspensions. From dosage — effectivity relations obtained isoeffective inhibitory values pc 50 1 show a strong substituent dependence, which was used for structure — activity studies. In this way four separate relations between activity data pc 50 and hydrophobic molecule parameters were found for typical substituent positions. The results of this paper are discussed and compared with analogous QSAR of earlier tested series of related compounds (1-amino-3-alkylguanidines, urea and thiourea derivatives).
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