Abstract
The knockdown activity of tetramethrin and related compounds with various imide and lactam structures in the alcohol moiety was measured against house flies under conditions in which metabolic factors were minimized by inhibitors. Variations in the activity were analyzed quantitatively by use of physicochemical parameters of the alcohol moiety and regression analysis. Compounds including tetramethrin, which have a symmetry plane perpendicular to the imide moiety, had higher knockdown activity than others when other physicochemical properties were the same. Taking into consideration this symmetry factor, the most significant parameters correlated with the variations in the activity were hydrophobicity and a steric dimension. Greater hydrophobicity produced higher activity. There was an optimum steric bulkiness represented by the van der Waals volume in the alcohol moiety for the activity. The structural effects agreed well with those expected from both meta- and para-substituted benzyl chrysanthemates for position-specific effects.
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