Abstract
Endothelin-1 analogs replaced by various amino acids at position 20 [X 20]-ET-1) were synthesized and evaluated for the ET A and ET B receptor binding activities. In order to obtain the structural requirements for the ET A and ET B receptor binding activities, the quantitative structure-activity relationships(QSAR) of sixteen analogs was investigated by the PLS method. The quantitative structuve-activity relationshis(QSAR) of endothelin-1 analogs([X20]-ET-1) replaced by various amino acids at position 20 was investigated by the PLS method.
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