Abstract
Triadimefon is a known potent inhibitor of ergosterol biosynthesis in yeasts and fungi and belongs to the Phenoxy-triazolyl-methane group We report on quantitative structure-activity relationship studies according to Hansch in the phenoxy-triazolyl-methane series based on MIC-values against Saccharomycopsis lipolytica in the agar diffusion test and, in comparison, based on 50% inhibition-values for ergosterol biosynthesis in the same yeast. The correlation deduced show that principally pI50-values of ergosterol biosynthesis inhibition in yeast and fungi are of value as biological data in quantitative structure-activity studies in this azole group.
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