Quantitative structure-activity relationships: the Van't Hoff heats of transfer of resorcinol monoethers from water to n-octanol.

Abstract

The partition coefficients of resorcinol and some resorcinol monoalkyl-ethers from water to n-octanol have been measured as a function of temperature. These data are used to evaluate delta G, delta H and delta S for the solute transfer process. The data suggest direct calorimetric measurement of these parameters should be performed. Correlation with calorimetrically determined 'biological response' will permit a more detailed and precise commentary upon the quantitative structure-activity relationships for these compounds.