Abstract
Antimicrobial peptides are antimicrobial agents with high bioactivity and low bacterial resistance, which inspire scientists to recognize AMPs as appealing candidates for microbial infection treatments. QSAR modeling is one of the most important techniques in computer-aided drug design that is typically beneficial to promoting the design of AMPs. This paper presents an overview about breakthroughs and achievements in AMPs designed by QSAR modeling in recent 10 years, and primarily talks about 6 successful AMPs discoveries covering different QSAR models and solving various antimicrobial problems such as biological activity, cytotoxicity and bacterial resistance, which is responsible for future developments in new generation of AMPs and optimization in QSAR modeling.
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