Abstract
In this study IGC50 (50% inhibitory growth concentration) values of 26 nitrobenzenes were determined for population growth endpoint of Paramecium caudatum. Quantitative structure activity relationships (QSARs) were developed using log of the inverse of the IGC50 (logIGC50-1) in mole liter as the dependent variable and 6 molecular descriptors (logP, 1XⅤ, I, 1Ka, ∑σ- and ELUMO) as the independent variables. Through multiplicate regression analysis, one best QSAR equation was obtained. The equation was used to estimate IGC50 for 7 analogues.
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