Abstract
Although differentiation between central chondroid tumors is important, their parallelism makes it a diagnostic conundrum for clinicians and radiologists. The objective of this study was to evaluate the efficiency of quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) in differentiating grade I chondrosarcomas from enchondromas. We reviewed SPECT/CT images of patients with enchondromas and grade I chondrosarcomas arising in the long bones. Volume, mean standardized uptake value (SUVmean), and maximum standardized uptake value (SUVmax) of tumors were calculated from SPECT/CT images. In addition, clinical characteristics and radiological information were assessed. Of a total of 34 patients, 14 had chondrosarcomas. Chondrosarcoma group had significantly larger volume, and higher SUVmean and SUVmax of tumors than enchondroma group. There was no significant difference in age and tumor size between two groups. Areas under the receiver-operating characteristic curve (AUCs) for tumor volume, SUVmean, and SUVmax were 0.727, 0.757, and 0.875. In pairwise analyses, SUVmax had larger AUC than SUVmean (p = 0.0216). With a cut-off value of 15.6 for SUVmax, its sensitivity and specificity were 86% and 75% for differentiating between enchondroma and grade I chondrosarcoma. Quantitative SPECT/CT is a potential method to differentiate grade I chondroarcomas from enchondromas in patients with central chondroid tumors.
Highlights
Differentiation between central chondroid tumors is important because surgical treatment is the only curative management for patients with grade I chondrosarcoma
Fourteen patients were histologically confirmed as grade I chondrosarcoma after definitive surgery
There was no significant difference in age or tumor size between enchondroma and chondrosarcoma groups
Summary
Differentiation between central chondroid tumors is important because surgical treatment is the only curative management for patients with grade I chondrosarcoma. A wait-and-see policy is permissible for enchondromas in consideration of long-term prognosis[1,2] Their parallelism makes it a diagnostic conundrum for clinicians and radiologists to distinguish t hem[3]. Radionuclide uptake < Uptake to anterior iliac crest = Uptake to anterior iliac crest > Uptake to anterior iliac crest nuclear pleomorphism, high cellularity, and irregular distribution of cells are known as pathologic parameters with the most discriminating strength for differentiation of central grade I chondrosarcoma from e nchondroma[4]. No study has evaluated the utility of quantitative SPECT/CT for differentiation between chondroid tumors in the long bone. The objective of this study was to investigate the efficiency of quantitative SPECT/CT in differentiating grade I chondrosarcomas from enchondromas
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
