Abstract
Introduction: Inflammation is a major cause of arthritis. Since the conventional medicines used for the treatment of this disease have many side effects, herbal remedies can be proved to be effective in this case. So, the present study was aimed at investigating the quantitative detection of phytochemicals, screening of in vivo anti-inflammatory and the possible anti-arthritic activities of the crude methanol extracts of a traditional medicinal plant Macropanax dispermus leaves (MDML) and stem barks (MDMS). Methods: Quantitative screening of phytochemical constituents was analyzed by standard procedures. The in vivo anti-inflammatory activity was conducted on Swiss albino mice by using carrageenan and formalin-induced paw edema tests, and xylene-induced ear edema test. The possible anti-arthritic activity was done by evaluating the in vitro inhibition of bovine serum albumin (BSA) denaturation. Results: The current research showed that MDML contained a considerable amount of flavonoids and alkaloids, and MDMS contained a considerable amount of phenols. MDMS (200, 400 mg/kg) was observed to be an effective and significant (P < 0.001) peripheral anti-inflammatory agent in carrageenan and formalin-induced paw edema tests, whereas MDML (400 mg/kg) was observed to have an effective and significant (P < 0.001) neurogenic anti-inflammatory effect in xylene-induced ear edema test as compared to the negative control group. MDMS was observed to be an effective anti-arthritic agent as compared to that of the negative control group. All those effects were dose and concentration-dependent.Conclusion: The present research proved that MDML and MDMS were effective medications for the treatment of inflammation and arthritis.
Highlights
Inflammation is a major cause of arthritis
Materials and Methods Chemicals Methanol, gallic acid, quercetin, carrageenan, formalin, xylene, bovine serum albumin (BSA), and other chemicals used for the extraction, in vivo, and in vitro pharmacological tests were laboratory grade (Merck, Germany)
Quantitative phytochemical screening In the present study, it was found that Macropanax dispermus leaves (MDML) and MDMS contained a considerable quantity of phenol, flavonoid, and alkaloid
Summary
Inflammation is a major cause of arthritis. Since the conventional medicines used for the treatment of this disease have many side effects, herbal remedies can be proved to be effective in this case. It causes pain, swelling and stiffness of joints of bones [5] It can be treated by using drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressants, diseasemodifying anti-rheumatic drugs (DMARDs) and newer biological agents such as tumor necrosis factor alpha (TNFα) and monoclonal antibodies. Those drugs have severe side effects such as stomach irritation, malfunction of the kidney, urticaria, liver disorders, hematological abnormalities and gastrointestinal problems including ulcers, bleeding, heartburn, diarrhea, retention of fluid and perforation of stomach or intestine [6,7]. Due to the chronic nature of arthritis and adverse reactions of NSAIDs and DMARDs, the advanced aged arthritic patients tend to rely on alternative treatments that are effective, less toxic and reduce the load of taking regular multiple medicines
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
