Abstract
This study investigated the quantitative retention activity relationship of quinolones by using micellar liquid chromatography. Using different types of surfactants, retention behaviors of quinolones were studied. Based on the retention data, obtained from different micellar conditions, a quantitative retention - activity relationship was applied to the representative bacteria; E. coli, P. aeruginosa, and S. aureus. In the case of P. aeruginosa, a linear relationship was observed for CTAB, and SDS. On the other hand, no relationship was found for any kinds of bacteria, when the retention data, obtained from Brij 35, and SB 3–10 were applied. This study also matches these relationships to the quinolone active site, DNA gyrase, and explains its action mechanism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
