Quantitative result of 13C-Urea breath test does not correlate with Helicobacter pylori density in the stomach by assessing histopathology and grade of phenol red staining

Abstract

'Significant difference using Mann·Whitney U. All values displayed for 1M and non-1M medians 24 hour acid clearance for the two groups was examined. Results for percentage total acid exposure time (At), total number of reflux episodes (El)' total acid clearance time (ACTl).percentage erect acid exposure time (Ae ) , erect reflux episodes (Ee) , percentage supine acid exposure time (As)and supine reflux episodes (E,) were compared for the 1M and NIM groups using the Mann-Whitney U test. The median acid exposure of the 1M group of patients was shown to be significantly higher than the non-1M group (5.2% vs 2.8%). This was most clearly displayed in the supine period where both the number of reflux episodes (2 vs I) and the acid exposure (1.4% vs 0.2%) were increased with respect to the non-1M group. Overall, the 1M group showed a significant delay in their median oesophageal acid clearance time (2.9 min vs 2.1 min). Oesophageal manometry provides important evidence of the ability of patients to effectively clear refluxate. Therefore, in addition to providing valuable pre-surgical information, manometry assist in therapeutic management. Patients with 1M should be advised to incline the upper body during rest and be provided with prolonged pharmacological acid suppression at night.