Quantitative reconstruction of absorption and scattering coefficients in ultrasound-modulated optical tomography

Abstract

ABSTRACT The simultaneous and/or quantitative recovery of optical absorption and scattering coecients in ultrasound-modulated optical tomography requires the use of a model-based inversion procedure. In this work we employa linearised forward model as part of a non-linear image reconstruction process, recovering parameters with anerror of less than 3% from simulated measurements with 1% Gaussian noise and initial conditions di ering by10% from the actual background.Keywords: Ultrasound-modulated optical tomography, acousto-optics, image reconstruction, optical tomogra-phy, imaging 1. INTRODUCTION Ultrasound modulated optical tomography (UOT) is a hybrid imaging technique which combines the spatialresolution of ultrasound elds and the optical contrast of near infra-red light in biological media. A principlegoal of this developing technology is the reconstruction of clinically relevant quantitative images of the absorptionand scattering coecients in biological media, with a spatial resolution exceeding that of purely optical techniquessuch as di use optical tomography (DOT).