Abstract
Diffusion and transport of complex fluids in porous media have attracted significant interests not only due to their unique mechanics but also their close relevance to various biological systems. In this paper, we exhibit direct real-time visualization of the planar diffusion patterns of a nanofluid that is microfluidically injected and confined in the dermal layer of living mouse skin. An in vivo fluorescence bioimaging method enables the physiological monitoring of spatiotemporally-resolved diffusion behavior of fluorescent magnetic nanoparticle suspensions which are transcutaneously and continuously infused into the dermis using a microneedle-micropump device. We discuss the possible mechanism of this quasi-2D diffusion process based on a convection–diffusion model and future applications in the context of bioengineering, including magnetic hyperthermia and controlled drug delivery.
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