Abstract
Diffuse reflectance near-infrared (NIR) spectroscopy is a non-invasive and widely used technology with the potential for a wide range of applications in the pharmaceutical industry, ranging from raw material identification to final product qualification. [...]
Highlights
Diffuse reflectance near-infrared (NIR) spectroscopy is a non-invasive and widely used technology with the potential for a wide range of applications in the pharmaceutical industry, ranging from raw material identification to final product qualification
Powder blending processes, as one of the key unit operations for solid dosage forms can be monitored in real-time for the blend quality and blending time until uniformity
Common NIR systems enable single point measurements at dedicated positions of the blender, based on the assumption, that the sampled position represents the whole blend. This is a problematic task as the mixing characteristics of powders significantly change (e. g., segregation, agglomeration, etc.) with the process parameters
Summary
Diffuse reflectance near-infrared (NIR) spectroscopy is a non-invasive and widely used technology with the potential for a wide range of applications in the pharmaceutical industry, ranging from raw material identification to final product qualification. Quantitative Quasi-Simultaneous and Spatially Resolved Real-time Monitoring of Powder Mixing 1 Research Center Pharmaceutical Engineering GmbH, Graz, Austria 2 Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
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