Quantitative phospholipidomics and screening for significantly different phospholipids in human colostrum and milk, and dairy animal colostrum

Abstract

Phospholipids (PLs) in milk have various physiological functions. Herein, the dynamic alterations of PLs between human colostrum, transitional and mature milk were studied by phospholipidomics. Additionally, the PL profiles of human colostrum and six dairy animal colostrum (mare, camel, goat, cow, yak, and buffalo colostrum) were characterised and compared. The difference between human colostrum, transitional and mature milk was primarily from the decrease of phosphatidylcholine content. Glycerophospholipid metabolism was the most relevant of the 27 metabolic pathways involved in lactation. Camel colostrum was the most similar to human colostrum, with respect to PLs. This study helps to understand the PL alteration mechanisms of human colostrum and milk, and provides a reference for the refined simulation of human colostrum and the selection of infant formula raw materials.