Abstract
A cellular-level study of the pathophysiology is crucial for understanding the mechanisms behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques show promises for the cellular-level understanding of the pathophysiology of diseases. To provide important insight on how the QPI techniques potentially improve the study of cell pathophysiology, here we present the principles of QPI and highlight some of the recent applications of QPI ranging from cell homeostasis to infectious diseases and cancer.
Highlights
Cellular metabolism and activities play crucial roles in the pathophysiology of human diseases.the cellular-level understanding of the mechanisms of the diseases holds the key to unlocking the secrets of a number of diseases
A series of 3D quantitative phase imaging (QPI) techniques have been developed to measure the 3D distributions of refractive index (RI) in biological cells, which offer a non-invasive means to probe the structural information of living cells without using exogenous labeling agents
With the optical field image measured by QPI, one can numerically calculate a far-field light scattering pattern of the sample by applying the 2.1. Two-Dimensional (2-D) Fourier transformation; this technique is called Fourier transform light scattering (FTLS) [64]
Summary
Cellular metabolism and activities play crucial roles in the pathophysiology of human diseases. The past few decades witnessed the emergence of several novel optical imaging techniques developed in physics laboratories and their translation into the fields of biology and medicine. Numerical focusing by the propagation of a reconstructed field image [6,7]. This has opened the door for direct analysis of live cells and their pathophysiological alterations. The research work, highlighted in this article, suggests that various QPI methodologies may play a crucial role in answering contemporary questions in the pathophysiology of cells and tissues which could, bring a substantial improvement in the understanding, assessment and treatment of diseases
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