Abstract
We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allowed us to extract Young's modulus of biological tissue. We experimentally calibrated our qOCE instrument, and validated its effectiveness on tissue mimicking phantoms and biological tissues.
Highlights
Optical coherence tomography (OCT) is a versatile, high-resolution imaging technique, with great potential in tissue characterization for various biomedical applications such as cancer diagnosis or surgical guidance [1, 2]
In addition to structural imaging, OCT can be used to perform mechanical characterization of biological tissue with one of its functional extensions referred as optical coherence elastography (OCE) [3,4,5,6,7,8,9,10]
To obtain quantitative measurements of tissue elasticity, we proposed a novel quantitative optical coherence elastography technology that measures tissue elasticity using a miniature probe with integrated force sensing functionality [24,25,26]
Summary
Optical coherence tomography (OCT) is a versatile, high-resolution imaging technique, with great potential in tissue characterization for various biomedical applications such as cancer diagnosis or surgical guidance [1, 2]. In addition to structural imaging, OCT can be used to perform mechanical characterization of biological tissue with one of its functional extensions referred as optical coherence elastography (OCE) [3,4,5,6,7,8,9,10]. Compression OCE based on a miniature fiber optic probe has a great potential for in situ characterization of mechanical properties of biological tissue. To obtain quantitative measurements of tissue elasticity, we proposed a novel quantitative optical coherence elastography (qOCE) technology that measures tissue elasticity using a miniature probe with integrated force sensing functionality [24,25,26]. The qOCE system developed in this study is significantly different from its predecessors, because it simultaneously measures the force/stress exerted on the tissue and the resultant tissue deformation/strain. We presented qOCE measurement results obtained from biological tissue
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