Abstract
Male Fischer 344 rats received cerebral irradiation at 300 rad/day, four days/wk for three wk, to a total dose of 3600 rad. The capillary permeability coefficients for galactitol, urea, and sodium determined at 6, 10 and 12 wk postirradiation were not statistically different when they were compared to control rats. We found no evidence for the “early” delayed effects of X irradiation based on alteration of brain capillary permeability. We feel this syndrome is the result of alteration in the processes that control the maintenance of myelin. Further investigation of cellular and biochemical effects of irradiation would be more informative than additional capillary membrane studies.
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More From: International Journal of Radiation Oncology, Biology, Physics
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