Abstract
Objective To determine the diagnostic value of quantitative motor unit potential (MUP) analysis and peak-ratio analysis of the turns amplitude analysis (Fuglsang-Frederiksen et al., 1992) in electrophysiological diagnosis of myopathy. Methods Electromyography (EMG) data of 163 patients consecutively referred for myopathy and in whom both MUP and peak-ratio analysis were done in biceps brachii (BB) muscle were analysed retrospectively. MUP and peak ratio analysis data from BB muscle were compared. Results Of 163 patients, the overall clinical and electrophysiological diagnosis estimated using the whole electrophysiological examination was myopathy in 97 patients, normal in 45 and other disorders in 21. In 97 myopathy patients, both MUP and peak-ratio analysis were myopathic in 33 BB muscles (34%), whereas 20 muscles (21%) showed normal peak-ratio but myopathic MUP and 26 muscles (27%) showed myopathic peak-ratio but normal MUP analysis. Overall, myopathic changes were seen in 79 muscles (82%). In 39 of 45 subjects without abnormality (87%) and in 18 of 21 subjects (86%) with other disorders, both MUP and peak-ratio analysis were normal without myopathic changes. Conclusion MUP and peak-ratio analysis supplement each other in electrophysiological diagnosis of myopathy.
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