Abstract
A microemulsion electrokinetic chromatography (MEEKC) method has been developed and validated for the determination of both naproxen and rizatriptan benzoate and their degradation products. This method is based on a previously reported generic procedure using widely applicable separation conditions with no additional method development. The methods were shown to be stability indicating and quantitative. Accuracy, linearity, and repeatability were good. Internal standards were employed to improve injection precision and detector linearity. An LOD of 0.2 μg mL–1 for naproxen and 1 μg mL–1 for rizatriptan benzoate was obtained. This work is the first reported validated MEEKC method for these drugs and shows that a generic methodology can be successfully implemented in routine quality control testing.
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