Abstract
In order to evaluate the survival of stem cells, after treatment with some anticancer drugs, two assays were carried out based on the ability of the stem cells to produce spermatocytes, spermatids and spermatozoa. These assays comprise the measurement of the levels of the enzyme LDH-X and the number of sperm heads in testicular homogenates. LDH-X is the X isozyme of lactate dehydrogenase which in mammals is found only in testis and spermatozoa (Wheat and Goldberg 1975). LDH enzyme levels provide a “fingerprint” in the study of spermatogenesis (Bishop 1968).
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Schedule a callMore From: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
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