Abstract
MRI-guided radiotherapy systems have the potential to bring two important concepts in modern radiotherapy together: adaptive radiotherapy and biological targeting. Based on frequent anatomical and functional imaging, monitoring the changes that occur in volume, shape as well as biological characteristics, a treatment plan can be updated regularly to accommodate the observed treatment response. For this purpose, quantitative imaging biomarkers need to be identified that show changes early during treatment and predict treatment outcome. This review provides an overview of the current evidence on quantitative MRI measurements during radiotherapy and their potential as an imaging biomarker on MRI-guided radiotherapy systems.
Highlights
At the turn of the century, two novel concepts were introduced in radiation oncology that acknowledged the complexity of tumor biology and that presented the challenges that must be met to improve the outcome of radiotherapy
Based on frequent imaging, monitoring the changes that occur in volume, shape as well as biological characteristics, a treatment plan can be updated regularly to Frontiers in Oncology | www.frontiersin.org van Houdt et al Quantitative MRI for biological image-guided adaptive radiotherapy (BIGART)
We summarize the current evidence on repeated Quantitative MRI (qMRI) measurements during radiotherapy and the potential for such an approach with MRI-guided radiotherapy (MRIgRT) systems
Summary
Heide UA (2021) Quantitative Magnetic Resonance Imaging for Biological Image-Guided Adaptive. MRI-guided radiotherapy systems have the potential to bring two important concepts in modern radiotherapy together: adaptive radiotherapy and biological targeting. Based on frequent anatomical and functional imaging, monitoring the changes that occur in volume, shape as well as biological characteristics, a treatment plan can be updated regularly to accommodate the observed treatment response. For this purpose, quantitative imaging biomarkers need to be identified that show changes early during treatment and predict treatment outcome. This review provides an overview of the current evidence on quantitative MRI measurements during radiotherapy and their potential as an imaging biomarker on MRI-guided radiotherapy systems
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