Abstract
Knowledge of the radiant energy fluence rate in tissues during laser irradiation is important for the understanding and improvement of the results of preclinical as well as clinical treatments. Quantitative data are extremely rare, however. In this paper, quantitative measurements of energy fluence rates are reported, in vitro as well as in vivo, with emphasis on light dosimetry for photodynamic therapy. Examples are given of fluence rate distributions that may occur during surface irradiation, intracavity irradiation of hollow organs (bladder) and interstitial irradiation. For the same incident irradiance, the energy fluence rate in tissue may vary considerably, depending on type of tissue, wavelength and geometry. During experimental and clinical interstitial PDT-treatments a considerable decrease in light penetration into tumours was observed, apparently indicating changes in optical properties as a result of treatment. This demonstrates the importance of in vivo light dosimetry.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
